Spectrophotometric Determination of Losartan Potassium in Tablets

  • Arianne Diane A. Aniñon University of the Philippines Manila
  • Richard Simon R. Binos University of the Philippines Manila
  • Karen Mae M. Brizuela University of the Philippines Manila
  • Willison John C. de Luna University of the Philippines Manila
  • Regine Philline S. del Rosario University of the Philippines Manila
  • Jesus John C. Dimalala University of the Philippines Manila
  • Timothy Joseph P. Dueñas University of the Philippines Manila
  • Isaac Ireneo B. Linatoc University of the Philppines Manila
  • Juan Paolo D. Recto University of the Philippines Manila
  • Melanie V. Salinas University of the Philippines Manila
  • West Kristian D. Paraiso University of the Philippines Manila

Abstract

In the quality control of pharmaceutical products, it is of utmost importance that validated analytical methods are used to ensure the credibility of the results generated. At the time of the study, official monographs from the United States Pharmacopeia and National Formulary (USP-NF) for the quantification of Losartan potassium in tablets were unavailable, denoting the need for a validated analytical procedure for the analysis of the drug. The study adapted direct and first-derivative UV spectrophotometry methods proposed by Bonfilio and others (2010) for the assay of Losartan potassium in Losartan 50 mg. capsules, then modified and validated the said procedures for the assay of Losartan potassium in Losartan 100 mg. tablets following the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines on method validation for accuracy, precision, specificity, linearity, limit of detection, and limit of quantitation. Results demonstrated that all the performance characteristics of both methods were highly satisfactory and confirmed the possible application of the methods in routine analysis of Losartan potassium tablets.

Keywords: Losartan Potassium, UV spectrophotometric determination, assay validation, direct and first-derivative spectra, hypertension

Issue
Vol 26 No 1 (2014)
Section
Communications
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